Job Description Summary

The Department of Pathology and Laboratory Medicine at the Medical University of South Carolina (MUSC) invites applications for a postdoctoral researcher position in Alzheimer’s disease (AD) research. We are seeking a highly motivated research scholar to study the role of cellular senescence in brain aging and AD pathogenesis. The successful candidate will utilize an array of state-of-the-art approaches, including cellular & molecular biology techniques, single-cell RNA sequencing, flow cytometry, confocal microscopy, and AD transgenic animal models, to delineate how senescent cells affect amyloid plaque formation, tau pathologies, neuroinflammation and AD progression. Applicants should have a recent Ph.D. in neurobiology, molecular cell biology, neuroscience, or other related fields. Interested applicants should send your CV, a cover letter describing your research interests/previous experience/future career goals, and the contact information for three references to Dr. Gavin Wang at Competitive salary and benefits will be commensurate with qualifications and experience. Previous experience working with transgenic mouse models of AD and confocal microscopy is highly preferred.

Job Duties

30% - In consultation with the PI, design and execute experiments to advance independent research projects. S/he will be responsible for planning experiments, developing new assays and experimental models as needed, troubleshooting, data analysis and interpretation, and being able to incorporate the results into manuscripts and sections of grant proposals.
30% - Conduct standard animal experiments, including the handling of transgenic mice, mouse intraperitoneal and tail vein injections, rodent general surgeries (specific surgical procedures can be learned and trained as needed), collecting tissues, IHC, and data analysis.
25% - Perform specific assays including histological procedures, quantitative RT-PCR, immunoblotting, immunofluorescence, confocal microscopy, and flow cytometry assays.
10% - Assist the PI in training and supervising graduate students, technicians, research assistants and junior lab members.
5% - Attend seminars, career development activities locally and nationally at conferences, submit abstracts and present data at local, national & international meetings, and if applicable write postdoctoral fellowship applications and grant proposals.

Minimum Experience and Training Requirements

Candidates should have a Ph.D. in neuroscience, molecular cell biology, cellular neurobiology, or any other related fields.

Preferred Experience & Additional Skills

Expert-level intellectual input to the research objectives and data interpretation of the PI’s projects.
Ability to work independently in experimental design and project execution.
Good oral and written communication skills.
Ability to train and supervise technicians and graduate students.

Additional Job Description

Physical Requirements: (Note: The following descriptions are applicable to this section: Continuous - 6-8 hours per shift; Frequent - 2-6 hours per shift; Infrequent - 0-2 hours per shift) Ability to perform job functions in an upright position. (Continuous) Ability to perform job functions in a seated position. (Continuous) Ability to perform job functions while walking/mobile. (Frequent) Ability to climb stairs. (Infrequent) Ability to work indoors. (Continuous) Ability to work in all cold temperature extremes, i.e. spot coolers. (Frequent) Ability to bend at the waist. (Frequent) Ability to twist at the waist. (Frequent) Ability to perform 'pinching' operations. (Continuous) Ability to fully use both hands/arms. (Continuous) Ability to perform repetitive motions with hands/wrists/elbows and shoulders. (Continuous) Ability to fully use both legs. (Continuous) Ability to reach in all directions. (Continuous) Possess good finger dexterity. (Continuous) Ability to maintain tactile sensory functions. (Continuous) Ability to maintain good olfactory sensory function. (Continuous) Ability to lift and carry 15 lbs., unassisted. (Frequent) Ability to lift objects, up to 15 lbs., from floor level to height of 72 inches, unassisted. (Frequent) Ability to lower objects, up to 15 lbs., from height of 72 inches to floor level, unassisted. (Frequent) Ability to push/pull objects, up to 15 lbs., unassisted. (Infrequent) Ability to lift and carry objects up to 15 lbs. a distance of five (5) floors and to outlying buildings. (Frequent) Ability to maintain 20/40 vision, corrected. (Continuous) Ability to see and recognize objects close at hand. (Continuous) Ability to see and recognize objects at a distance. (Continuous) Ability to match or discriminate between colors. (Continuous) Ability to determine distance/relationship between objects; depth perception. (Continuous) Good peripheral vision capabilities. (Continuous) Ability to maintain hearing acuity, with correction. (Continuous) Ability to perform gross motor functions with frequent fine motor movements. (Continuous) Ability to be qualified physically (by medical personnel) for respirator use, initially and annually. Ability to work alone in isolated areas, such as darkrooms. (Frequent)

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Medical University of South Carolina

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